Rational Design of Evolutionarily Stable Microbial Kill Switches
نویسندگان
چکیده
منابع مشابه
Rational Design of Evolutionarily Stable Microbial Kill Switches.
The evolutionary stability of synthetic genetic circuits is key to both the understanding and application of genetic control elements. One useful but challenging situation is a switch between life and death depending on environment. Here are presented "essentializer" and "cryodeath" circuits, which act as kill switches in Escherichia coli. The essentializer element induces cell death upon the l...
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Biocontainment systems that couple environmental sensing with circuit-based control of cell viability could be used to prevent escape of genetically modified microbes into the environment. Here we present two engineered safeguard systems known as the 'Deadman' and 'Passcode' kill switches. The Deadman kill switch uses unbalanced reciprocal transcriptional repression to couple a specific input s...
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We develop an evolutionary approach to explain altruistic preferences. Given their preferences, individuals interact rationally with each other. By comparing the success of players with different preferences, we investigate whether evolution favors altruistic or selfish attitudes. The outcome depends on whether the individuals' interactions are strategic complements or substitutes. Altruism and...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2017
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2017.10.033